A recurrent miscarriage is defined as the loss of 3 (or 2) previous pregnancies and i's unclear whether treatment will improve pregnancy outcome in women with unexplained miscarriages.
About 1% of all women who are trying to conceive have 3 or previous miscarriages, and 5% have 2 previous miscarriages.
It has been suggested that certain treatments such as heparin and aspirin or both may help improve pregnancy outcome.
This study published in April 2010 in the New England Journal of Medicine by Kaandorp and co-authors from the Netherlands tried to look whether pregnancy outcomes were improved in women with these treatments:
- Aspirin only
- Aspirin plus nadroparin (similar to heparin)
- Placebo (no active medications)
The authors enrolled a total of 364 women who were randomly assigned to either of these 3 groups.
The authors concluded that neither aspirin alone or aspirine plus nadroparin had improved outcomes as compared to no active treatment.
They concluded that their findings do not support the hyopthesis that either combination therapy of aspirin with or without nadroparin as compared to no treatment improved the chance of a live birth in women with unexplained recurrent miscarriage.