We are not the only inhabitants of our bodies. Each adult human body plays host to roughly 10 million microscopic organisms that help maintain health from head to toe. Those that inhabit the vagina are important for reproductive health, healthy fetal development, and may even influence the child’s risk for eczema and allergies during infancy.
A great deal of study is under way to learn more about the vaginal microbiome (collection of bacteria, fungi, yeast, and other microbial inhabitants). When an overgrowth of one species outnumbers others, medical conditions such as bacterial vaginosis (BV) and urinary tract infections (UTIs) can develop. Recent studies indicate an imbalance of microbial species (dysbiosis) contributes to the risk factor for dangerous inflammation during pregnancy, when it can lead to premature delivery and other complications of pregnancy and childbirth.
The Vaginal Microbiome
The vast majority of the human microbiome is in the digestive system. The different species of microbes and how many of each there are depend on a person’s diet, state of health, drugs being used, lifestyle (urban or rural, developed or undeveloped nation), gender, race, age, and other demographic factors. The diversity from person to person is immense.
This is not the case with the vaginal microbiome, however. Composition of the vaginal microbiome is very similar in all women of reproductive age, regardless of other demographic factors. This similarity has intrigued Dr. Gregor Reid for 33 years, since early in his career as a microbiome and probiotics scientist.
The Role of Lactobacilli
Reid, now affiliated with the Lawson Health Research Institute and the University of Western Ontario, both in London, Ontario, is hard at work to develop a lactobacilli-based treatment for BV and UTI that doesn’t require antibiotics. There are several strains of the lactobacilli bacterium that make up a significant part of the vaginal microbiome. When harmful or foreign microbes (pathogens) crowd out the lactobacilli colony, infection occurs.
Since lactobacilli are so abundant in the vaginal microbiome and this microbiome is so similar in all women, Reid feels it must be instrumental to reproductive health, pregnancy, and fetal development. Babies are exposed to the maternal microbiome during during gestation and vaginal delivery perhaps to help start their own microbiomes and immune-system development. Lactobacilli are present in breast milk, too.
“To fully understand female health, reproduction and infant development, we need to better understand lactobacilli,” said Reid. He finds the study of the vaginal microbiome tricky, however, due to impossible-to-control factors that include the menstrual cycle, sexual activity, immune response, and the use of personal hygiene products that include douches.
Lactobacilli’s Influence Postpartum and During Infancy
A team of researchers in New Zealand recently announced the launch of a study to explore what effect the probiotic Lactobacillus rhamnosus HN001 has on pregnancy, postpartum health, and infant health. The researchers will enroll 400 pregnant women during their 14th to 16th week of gestation. All women will be expecting babies at high risk for eczema and allergies.
Some of the women will be given Lactobacillus supplements to take until they give birth. If they breastfeed, they will continue supplementation for six months postpartum. The other women will take placebos.
The main goal of the study is to measure the effect of the probiotic supplements on the child’s development of allergies or eczema during its first year. Other outcomes that will be monitored include:
- Development of gestational diabetes.
- Development of BV and the presence of a particular Streptococcus bacterium at 35 to 37 weeks gestation.
- Maternal weight gain.
- Postpartum depression and anxiety.
- Infant birth weight.
- Preterm birth.
- Rate of caesarean deliveries.
The researchers will test samples of maternal and infant fecal samples, maternal and cord blood samples, and breast milk. Infant skin and cheek swabs will also be tested. The researchers hope to discover if treating only the mother during pregnancy and breastfeeding will reduce the child’s risk for allergies and eczema without treating the baby itself.
Reid, Gregor. "Cervicovaginal Microbiomes–Threats and Possibilities." Editorial. Trends in Endocrinology & Metabolism / Elsevier Inc. (2016). Cell. Web. 10 June 2016.
Barthow, C, et al. "The Probiotics in Pregnancy Study (PiP Study): rationale and design of a double-blind randomised controlled trial to improve maternal health during pregnancy and prevent infant eczema and allergy." PubMed. BMC Pregnancy and Childbirth / Springer Science+Business Media, 3 June 2016. US National Library of Medicine / National Institutes of Health. Web. 10 June 2016.
"Lactobacillus." Encyclopædia Britannica. Encyclopædia Britannica, Inc., n.d. Web. 10 June 2016.