Researchers from the University of Padua in Italy recently evaluated the outcome of pregnancies in women testing positive for antiphospholipid but lacking clinical presentation of the condition. The treatment group received low-dose aspirin (LDA). The control group received no treatment. Factors taken into consideration included pregnancy loss, fetal age at delivery and birth weight. One hundred fourteen women of 139 participants tested positive for antiphospholipid. The remaining women were retained as the control group.

Women in the active group who received LDA did not differ significantly from women in the control group. The only difference noted between the two groups was in birth weight when mothers tested positive for lupus anticoagulant and certain glycoprotein antibodies.

Conclusion: LDA treatment does not affect pregnancy outcome in women who present with positive antiphospholipid results independent of criteria to diagnose a medical condition.

Source: Del Ross T, Ruffatti A, Visentin MS, Tonello M, Calligaro A, Favaro M, Hoxha A, Punzi L. Treatment of 139 Pregnancies in Antiphospholipid-positive Women Not Fulfilling Criteria for Antiphospholipid Syndrome: A Retrospective Study. J Rheumatol. 2013 Feb 15.

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