Breast pain and tenderness after ovulationis due to an increase of the hormone progesterone. Breast tenderness during menopause is due to a hormone imbalance.In most cases, an unbalanced level of estrogen hormones is the main cause for breast tenderness during menopause.

The most common cause of breast tenderness during menopause is hormonal imbalance. During the menstrual cycle, estrogen and progesterone levels vary in different ways. Normally, when estrogen is down and progesterone is up, breasts get bigger in size and start being tender and hurt. But during and shortly before menopause hormonal imbalance can alter this cycle, making breasts even bigger and more susceptible to pain, and for more prolonged periods. Therefore, when hormones are not balanced and estrogen levels decrease more than progesterone, the end result is breast tenderness during menopause.