Q: I have a Robertsonian 21/22 translocation. What are the odds that my child will have Down Syndrome?
A: Individuals with a balanced 21/22 Robertsonian translocation look normal and are phenotypically not different from other people who do not have this translocation. When they have a child, the child has about a 10% chance of having Down Syndrome, and if it doesn't have Down Syndrome, the child will also have a 21/22 translocation, like the parent.