Researchers from Yale University School of Medicine recently published a case study on a woman of 36 years who underwent two cycles clomiphene citrate with the second cycles occurring after an undetected pregnancy resulting from the first study.

The patient underwent a cycle of clomiphene citrate and ovulation induction. When the cycle was deemed unsuccessful, she underwent a second cycle. Pregnancy was detected after the second cycle, but transvaginal ultrasound revealed the pregnancy occurred after the first cycle. The fetus was exposed to fertility drugs, which could cause pregnancy and/or fetus complications.

When multiple assisted reproductive cycles are suggested, doctors should use beta-HCG testing to rule out pregnancy between cycles, according to researchers. The study was published in the Journal of Reproductive Medicine.

Source: Kallen AN, Luk J, Pal L. Aberrant endocrinology and ovarian response to clomiphene citrate during the course of an undiagnosed early intrauterine pregnancy: a case report. J Reprod Med. 2013 May-Jun;58(5-6):256-60.