Researchers from the Warwick Medical School have recently completed a study that correlates recurrent miscarriage with a possible flaw in the fertility window. The fertility cycle typically offers two to three days when fertility is optimal, but when that window is extended the uterine environment changes and the changes cause problems with implantation that could lead to recurrent miscarriage.
During the menstrual cycle, the female body releases cytokine IL-33. Cytokine activates receptors in the uterus that cause inflammation. It is the two to three days when cytokine is active when women are most fertile, but in some women with recurrent miscarriage, the inflammatory stage is longer than normal leading to improper implantation. When the embryo does not implant properly, the body can spontaneously abort the pregnancy leading to miscarriage. As long as the inflammatory cycle remains out of sync, miscarriage could recur.
Researchers taking part in the study believe the results could prove beneficial in terms of future treatment for women suffering recurrent miscarriage. The inflammatory response is already the subject of medical study in terms of effect on asthma, cardiovascular disease, Alzheimer’s and autoimmune conditions. If doctors can regulate the inflammatory cycle, women who once thought carrying a pregnancy to term was impossible may be given a renewed sense of hope and the medical support they need to successfully conceive, carry and birth a child.
The study will be published in the journal PLoS One.
Source: Warwick Medical School